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1

Construction of a Large Phage-Displayed Human Antibody Domain Library with a Scaffold Based On a Newly Identified Highly Soluble, Stable Heavy Chain Variable Domain

Weizao Chen, Zhongyu Zhu, Yang Feng, Xiaodong Xiao, Dimiter S. Dimitrov

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 836 KB

english, 2008

2

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

Xiao, Xiaodong, Chen, Weizao, Feng, Yang, Dimitrov, Dimiter S.

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 652 KB

english, 2009

3

Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins

Chen, Weizao, Zhu, Zhongyu, Liao, Huaxin, Quinnan, Gerald V., Broder, Christopher C., Haynes, Barton F., Dimitrov, Dimiter S.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 178 KB

english, 2010

4

Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats

Zhang, Liangjun, Cheng, Ying, Du, Xiaohuang, Chen, Sheng, Feng, Xinchan, Gao, Yu, Li, Shaoxue, Liu, Li, Yang, Mei, Chen, Lei, Peng, Zhihong, Yang, Yong, Luo, Weizao, Wang, Rongquan, Chen, Wensheng, Ch

Journal:

Evidence-based Complementary and Alternative Medicine

Année:

2015

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2015

5

Antibody Aggregation: Insights from Sequence and Structure

Li, Wei, Prabakaran, Ponraj, Chen, Weizao, Zhu, Zhongyu, Feng, Yang, Dimitrov, Dimiter

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 3.53 MB

english, 2016

6

Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Li, Wei, Zhu, Zhongyu, Chen, Weizao, Feng, Yang, Dimitrov, Dimiter S.

Journal:

Frontiers in Immunology

Année:

2017

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2017

7

Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations

Ponraj Prabakaran, Weizao Chen, Maria G. Singarayan, Claudia C. Stewart, Emily Streaker, Yang Feng, Dimiter S. Dimitrov

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 740 KB

english, 2012

8

Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates

Weizao Chen, Xiaodong Xiao, Yanping Wang, Zhongyu Zhu, Dimiter S. Dimitrov

Journal:

Antiviral Research

Année:

2010

Langue:

english

Fichier:

PDF, 882 KB

english, 2010

9

Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or β-galactosidase as a carrier of immunogenic epitopes

Guangjin Li, Weizao Chen, Weiyao Yan, Kai Zhao, Mingqiu Liu, Jun Zhang, Liang Fei, Quanxing Xu, Zutian Sheng, Yonggan Lu, Zhaoxin Zheng

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 270 KB

english, 2004

10

Cross-inhibition to heterologous foot-and-mouth disease virus infection induced by RNA interference targeting the conserved regions of viral genome

Mingqiu Liu, Weizao Chen, Zheng Ni, Weiyao Yan, Liang Fei, Ye Jiao, Jun Zhang, Qingyun Du, Xuefeng Wei, Jiulian Chen, Yumei Liu, Zhaoxin Zheng

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 562 KB

english, 2005

11

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

Xiaodong Xiao, Weizao Chen, Yang Feng, Zhongyu Zhu, Ponraj Prabakaran, Yanping Wang, Mei-Yun Zhang, Nancy S. Longo, Dimiter S. Dimitrov

Journal:

Biochemical and Biophysical Research Communications

Année:

2009

Langue:

english

Fichier:

PDF, 352 KB

english, 2009

12

Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

Weizao Chen, Emily D. Streaker, Daniel E. Russ, Yang Feng, Ponraj Prabakaran, Dimiter S. Dimitrov

Journal:

Biochemical and Biophysical Research Communications

Année:

2012

Langue:

english

Fichier:

PDF, 644 KB

english, 2012

13

Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies

Weizao Chen, Yang Feng, Yanping Wang, Zhongyu Zhu, Dimiter S. Dimitrov

Journal:

Biochemical and Biophysical Research Communications

Année:

2012

Langue:

english

Fichier:

PDF, 885 KB

english, 2012

14

RNA silencing: A remarkable parallel to protein-based immune systems in vertebrates?

Weizao Chen, Mingqiu Liu, Gong Cheng, Weiyao Yan, Liang Fei, Zhaoxin Zheng

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 114 KB

english, 2005

15

Characterization of the porcine alpha interferon multigene family

Gong Cheng, Weizao Chen, Zuofeng Li, Weiyao Yan, Xin Zhao, Jun Xie, Mingqiu Liu, Hao Zhang, Yang Zhong, Zhaoxin Zheng

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2006

16

Response to Bayry and Tough: Is RNAi useful for controlling foot-and-mouth disease outbreaks?

Weizao Chen, Weiyao Yan, Zhaoxin Zheng

Journal:

Trends in Immunology

Année:

2005

Langue:

english

Fichier:

PDF, 68 KB

english, 2005

17

A large human domain antibody library combining heavy and light chain CDR3 diversity

Weizao Chen, Zhongyu Zhu, Yang Feng, Dimiter S. Dimitrov

Journal:

Molecular Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2010

18

Characterization of human IgG repertoires in an acute HIV-1 infection

Weizao Chen, Ponraj Prabakaran, Zhongyu Zhu, Yang Feng, Emily D. Streaker, Dimiter S. Dimitrov

Journal:

Experimental and Molecular Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 887 KB

english, 2012

19

454 antibody sequencing - error characterization and correction

Ponraj Prabakaran, Emily Streaker, Weizao Chen, Dimiter S Dimitrov

Journal:

BMC Research Notes

Année:

2011

Langue:

english

Fichier:

PDF, 324 KB

english, 2011

20

Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design

Chen, Weizao, Ying, Tianlei, Dimitrov, Dimiter S

Journal:

Expert Opinion on Biological Therapy

Année:

2013

Langue:

english

Fichier:

PDF, 642 KB

english, 2013

21

Candidate Antibody-Based Therapeutics Against HIV-1

Gong, Rui, Chen, Weizao, Dimitrov, Dimiter S.

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 474 KB

english, 2012

22

Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1

Zhongyu Zhu, Ponraj Prabakaran, Weizao Chen, Christopher C. Broder…

Journal:

Virologica Sinica

Année:

2013

Langue:

english

Fichier:

PDF, 314 KB

english, 2013

23

Deep sequencing and Circos analyses of antibody libraries reveal antigen-driven selection of Ig VH genes during HIV-1 infection

Xiao, Madelyne, Prabakaran, Ponraj, Chen, Weizao, Kessing, Bailey, Dimitrov, Dimiter S.

Journal:

Experimental and Molecular Pathology

Année:

2013

Langue:

english

Fichier:

PDF, 2.67 MB

english, 2013

24

A new bispecific antibody targeting non-overlapping epitopes on IGF2: Design, in vitro characterization and pharmacokinetics in macaques

Feng, Yang, Zhao, Qi, Chen, Weizao, Wang, Yanping, Crowder, Karalyne, Dimitrov, Dimiter S.

Journal:

Experimental and Molecular Pathology

Année:

2014

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2014

25

Detection of Differential Expression of Porcine IFN- α Subtypes by Reverse Transcription Polymerase Chain Reaction

Cheng, Gong, Zhao, Xin, Chen, Weizao, Yan, Weiyao, Liu, Mingqiu, Chen, Jie, Zheng, Zhaoxin

Journal:

Journal of Interferon & Cytokine Research

Année:

2007

Langue:

english

Fichier:

PDF, 395 KB

english, 2007

26

Monoclonal Antibody-Based Candidate Therapeutics Against HIV Type 1

Chen, Weizao, Dimitrov, Dimiter S.

Journal:

AIDS Research and Human Retroviruses

Année:

2011

Langue:

english

Fichier:

PDF, 251 KB

english, 2011

27

Germlining of the HIV-1 broadly neutralizing antibody domain m36

Chen, Weizao, Li, Wei, Ying, Tianlei, Wang, Yanping, Feng, Yang, Dimitrov, Dimiter S.

Journal:

Antiviral Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2015

28

Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases

Ying, Tianlei, Feng, Yang, Wang, Yanping, Chen, Weizao, Dimitrov, Dimiter S.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 716 KB

english, 2014

29

The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires

Prabakaran, Ponraj, Chen, Weizao, Dimitrov, Dimiter S.

Journal:

Frontiers in Immunology

Année:

2014

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2014

30

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1

Chen, Weizao, Bardhi, Ariola, Feng, Yang, Wang, Yanping, Qi, Qianqian, Li, Wei, Zhu, Zhongyu, Dyba, Marzena A., Ying, Tianlei, Jiang, Shibo, Goldstein, Harris, Dimitrov, Dimiter S.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2016

31

Selective extraction of nitric and acetic acids from etching waste acid using N235 and MIBK mixtures

Chen, Fang, Wang, Xiaomei, Liu, Weizao, Liang, Bin, Yue, Hairong, Li, Chun

Journal:

Separation and Purification Technology

Année:

2016

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2016

32

Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors

Chen, Weizao, Dimitrov, Dimiter S

Journal:

Current Opinion in HIV and AIDS

Année:

2009

Langue:

english

Fichier:

PDF, 125 KB

english, 2009

33

128 Human domain antibodies against HIV-1 as exceptionally potent cross-reactive neutralizers

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Année:

2009

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2009

34

Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins

Pincus, Seth H., Song, Kejing, Maresh, Grace A., Hamer, Dean H., Dimitrov, Dimiter S., Chen, Weizao, Zhang, Mei-Yun, Ghetie, Victor F., Chan-Hui, Po-Ying, Robinson, James E., Vitetta, Ellen S.

Journal:

Journal of Virology

Année:

2016

Langue:

english

Fichier:

PDF, 3.52 MB

english, 2016

35

Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains

Qi, Qianqian, Wang, Qian, Chen, Weizao, Yu, Fei, Du, Lanying, Dimitrov, Dimiter S., Lu, Lu, Jiang, Shibo

Journal:

Journal of Infection

Année:

2017

Langue:

english

Fichier:

PDF, 497 KB

english, 2017

36

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

Qi, Qianqian, Wang, Qian, Chen, Weizao, Du, Lanying, Dimitrov, Dimiter S, Lu, Lu, Jiang, Shibo

Journal:

Emerging Microbes & Infections

Année:

2017

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2017

37

Indirect mineral carbonation of blast furnace slag with (NH 4 ) 2 SO 4 as a recyclable extractant

Hu, Jinpeng, Liu, Weizao, Wang, Lin, Liu, Qiang, Chen, Fang, Yue, Hairong, Liang, Bin, Lü, Li, Wang, Ye, Zhang, Guoquan, Li, Chun

Journal:

Journal of Energy Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 662 KB

english, 2017

38

Potent In Vivo NK Cell-mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-bispecific and Hexavalent Broadly Neutralizing Fusion Protein

Bardhi, Ariola, Wu, Yanling, Chen, Weizao, Zhu, Zhongyu, Zheng, Jian Hua, Wong, Hing, Jeng, Emily, Jones, Jennifer, Ochsenbauer, Christina, Kappes, John C., Dimitrov, Dimiter S., Ying, Tianlei, Goldst

Journal:

Journal of Virology

Année:

2017

Langue:

english

Fichier:

PDF, 4.69 MB

english, 2017

39

Graphene Oxide-Polycarbonate Track-Etched Nanosieve Platform for Sensitive Detection of Human Immunodeficiency Virus Envelope Glycoprotein

Nehra, Anuj, Chen, Weizao, Dimitrov, Dimiter S., Puri, Anu, Singh, Krishna Pal

Journal:

ACS Applied Materials & Interfaces

Année:

2017

Langue:

english

Fichier:

PDF, 2.94 MB

english, 2017

40

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

Li, Wei, Wu, Yanling, Kong, Desheng, Yang, Hongjia, Wang, Yanping, Shao, Jiping, Feng, Yang, Chen, Weizao, Ma, Liying, Ying, Tianlei, Dimitrov, Dimiter S.

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 3.36 MB

english, 2017

41

A defucosylated bispecific multivalent molecule exhibits broad HIV-1 neutralizing activity and enhanced ADCC against reactivated HIV-1 latently infected cells

Kong, Desheng, Wang, Yan, Ji, Ping, Li, Wei, Ying, Tianlei, Huang, Jinghe, Wang, Chen, Wu, Yanling, Wang, Yanping, Chen, Weizao, Hao, Yanling, Hong, Kunxue, Shao, Yiming, Dimitrov, Dimiter S., Jiang,

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2018

42

Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category

Boliar, Saikat, Patil, Shilpa, Shukla, Brihaspati N., Ghobbeh, Ali, Deshpande, Suprit, Chen, Weizao, Guenaga, Javier, Dimitrov, Dimiter S., Wyatt, Richard T., Chakrabarti, Bimal K.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2018

43

Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity

Wan, Chao, Sun, Jianping, Chen, Weizao, Yuan, Xiaohui, Chong, Huihui, Prabakaran, Ponraj, Dimitrov, Dimiter S., He, Yuxian, Jiang, Shibo

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2013

44

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Feng, Yang, Zhu, Zhongyu, Chen, Weizao, Prabakaran, Ponraj, Lin, Kedan, Dimitrov, Dimiter

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 319 KB

english, 2014

45

Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing

Prabakaran, Ponraj, Zhu, Zhongyu, Chen, Weizao, Gong, Rui, Feng, Yang, Streaker, Emily, Dimitrov, Dimiter S.

Journal:

Frontiers in Microbiology

Année:

2012

Langue:

english

Fichier:

PDF, 1.78 MB

english, 2012

46

A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells

Chen, Zhizhen, Liu, Jie, Chu, Dafeng, Shan, Yaming, Ma, Guixing, Zhang, Hongmin, Zhang, Xiaohua Douglas, Wang, Pu, Chen, Qiang, Deng, Chuxia, Chen, Weizao, Dimitrov, Dimiter S., Zhao, Qi

Journal:

International Journal of Biological Sciences

Année:

2018

Langue:

english

Fichier:

PDF, 873 KB

english, 2018

47

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

Schneider, Dina, Xiong, Ying, Hu, Peirong, Wu, Darong, Chen, Weizao, Ying, Tianlei, Zhu, Zhongyu, Dimitrov, Dimiter S., Dropulic, Boro, Orentas, Rimas J.

Journal:

Frontiers in Oncology

Année:

2018

Langue:

english

Fichier:

PDF, 3.59 MB

english, 2018

48

Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro

Wang, Hongqian, Wang, Yanping, Xiao, Zuoxiang, Li, Wei, Dimitrov, Dimiter, Chen, Weizao

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2019

49

Rapid elimination of broadly neutralizing antibodies correlates with treatment failure in the acute phase of SHIV infection

Wu, Yanling, Xue, Jing, Wang, Chunyu, Li, Wei, Wang, Lili, Chen, Weizao, Prabakaran, Ponraj, Kong, Desheng, Jin, Yujia, Hu, Dan, Wang, Yulu, Lei, Cheng, Yu, Diao, Tu, Chao, Bardhi, Ariola, Sidorov, Ig

Journal:

Journal of Virology

Année:

2019

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2019

50

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

Anthony-Gonda, Kim, Bardhi, Ariola, Ray, Alex, Flerin, Nina, Li, Mengyan, Chen, Weizao, Ochsenbauer, Christina, Kappes, John C., Krueger, Winfried, Worden, Andrew, Schneider, Dina, Zhu, Zhongyu, Orent

Journal:

Science Translational Medicine

Année:

2019

Langue:

english

Fichier:

PDF, 5.60 MB

english, 2019